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E7138 Sigma-Aldrich

Ethosuximide

Synonym: 2-Ethyl-2-methylsuccinimide

  • CAS Number 77-67-8

  • Empirical Formula (Hill Notation) C7H11NO2

  • Molecular Weight 141.17

  •  EC Number 201-048-7

  •  MDL number MFCD00072123

  •  PubChem Substance ID 24278423

  •  NACRES NA.77

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Properties

Related Categories Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   HAPOVYFOVVWLRS-UHFFFAOYSA-N
solubility   ethanol: 100 mg/mL
originator   Pfizer
Gene Information   human ... CACNA1G(8913)

Description

Application

Ethosuximide has been used:
• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

Packaging

5, 100 g in glass bottle

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. E7138.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WN2800000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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