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E8750 Sigma-Aldrich

α-Estradiol

powder, ≥98% (TLC)

Synonym: 1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
InChI Key   VOXZDWNPVJITMN-SFFUCWETSA-N
assay   ≥98% (TLC)
form   powder
color   white to slight yellow
solubility   ethanol: 50 mg/mL, clear, colorless
Gene Information   human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208)

Description

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
KG3750000

Documents

Certificate of Analysis

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Certificate of Origin

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Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I dissolve α-Estradiol, Product No. E8750?
This chemical is soluble in ethanol at 50 mg/mL with heating, and in DMSO at 27 mg/mL. Use of freshly prepared solutions is recommended.
What is the difference between α-Estradiol (Product No. E8750) and β-Estradiol?
α-Estradiol has been reported as being less feminizing than β-Estradiol while still having significant biological properties.See Moos, W.H., et al, "17α-Estradiol:a less-feminizing estrogen", Drug Development Research, 69(4), 177-184 (2008).
Is Product E8750, α-Estradiol, tested in cell culture?
No specific suitability tests for cell culture applications have been performed by Sigma. The product is not sterile and has not been tested for endotoxins.
My question is not addressed here, how can I contact Technical Service for assistance?
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Protocols & Articles

Articles

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MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

UHPLC Analysis of Conjugated Estrogens on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Conjugated Estrogens on Ascentis® Express C18
Keywords: Chromatography, Clinical, Solvents

UHPLC Analysis of Conjugated Estrogens on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Conjugated Estrogens on Titan™ C18
Keywords: Chromatography, Clinical, Solvents

UHPLC/MS Analysis of Estradiols using Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Estradiols using Ascentis® Express C18
Keywords: Mass spectrometry

Peer-Reviewed Papers
15

References

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