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F5682 Sigma-Aldrich

FH535

≥98% (HPLC)

  • Empirical Formula (Hill Notation) C13H10Cl2N2O4S

  • Molecular Weight 361.20

  •  MDL number MFCD01212888

  •  PubChem Substance ID 329799746

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: 20 mg/mL
storage temp.   2-8°C
SMILES string   Cc1cc(ccc1NS(=O)(=O)c2cc(Cl)ccc2Cl)[N+]([O-])=O
InChI   1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChI key   AXNUEXXEQGQWPA-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.

FH535 is a reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling antagonist. FH535 is unique in its ability to inhibit the Wnt/β-catenin pathway. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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