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F6892 Sigma-Aldrich

Farnesyl pyrophosphate ammonium salt

methanol:ammonia solution, ≥95% (TLC)

Synonym: 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt, FPP

  • CAS Number 13058-04-3

  • Empirical Formula (Hill Notation) C15H37N3O7P2

  • Molecular Weight 433.42

  •  MDL number MFCD00189688

  •  PubChem Substance ID 24894923




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Physical form

Solution in methanol: 10mM aqueous NH4OH (7:3)
Actual concentration given on label


Farnesyl pyrophosphate ammonium salt has been used:
•  as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
•  in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
•  as a substrate in prenyltransferases assay in diatom Haslea ostrearia

Biochem/physiol Actions

Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.

General description

Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).

Safety & Documentation

Safety Information

Signal word 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
Flash Point(F) 
60.8 °F
Flash Point(C) 
16 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Cholesterol Biosynthesis

Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the t...
BioFiles 2007, 2.7, 3.
Keywords: Catalysis, Decarboxylations, Metabolic Pathways, Oxidations, PAGE, Phosphorylations, Reductions

Dietary Terpenes

Terpenes comprise the largest and most diverse class of secondary metabolites; approximately 55,000 compounds have been identified to date.1 While the enzymes responsible for terpene synthesis are fo...
BioFiles 2008, 3.9, 4.
Keywords: Anti-inflammatory agents, Antimicrobials, Antiparasitics, Apoptosis, Building blocks, Cancer, Carcinogens, Cell division, Condensations, Detergents, Gene expression, Hormones, Insecticides, Isomerizations, Metabolites, Neurotransmitters, Poisons, Pollination, Reproduction, Vitamins

Peer-Reviewed Papers


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