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F7129 Sigma-Aldrich

5-Fluorocytosine

nucleoside analog

Synonym: 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine

  • CAS Number 2022-85-7

  • Empirical Formula (Hill Notation) C4H4FN3O

  • Molecular Weight 129.09

  •  Beilstein/REAXYS Number 127285

  •  EC Number 217-968-7

  •  MDL number MFCD00006035

  •  PubChem Substance ID 24894928

  •  NACRES NA.32

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action, Antifungal, Biochemicals and Reagents,
InChI Key   XRECTZIEBJDKEO-UHFFFAOYSA-N
assay   ≥99% (TLC)
mp   298-300 °C (dec.) (lit.)
Mode of action   DNA synthesis | interferes
  protein synthesis | interferes
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

General description

Chemical structure: nucleoside

Packaging

1, 5 g in poly bottle

Application

Used in studies on TMP biosynthesis.

Biochem/physiol Actions

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
HA6040000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical

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Peer-Reviewed Papers
15

References

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