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F8807 Sigma-Aldrich

FM19G11

≥98% (HPLC)

Synonym: 3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester, [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate

  • CAS Number 329932-55-0

  • Empirical Formula (Hill Notation) C23H17N3O8

  • Molecular Weight 463.40

  •  MDL number MFCD01174289

  •  PubChem Substance ID 329799774

  •  NACRES NA.77

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Metabolism, Cancer Research,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   off-white to light brown
solubility   DMSO: ≥40 mg/mL
storage temp.   2-8°C
SMILES string   Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI   1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
InChI key   XVUOIWIIQVGWAJ-UHFFFAOYSA-N

Description

Application

FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
• to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
• to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
• to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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