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F9145 Sigma-Aldrich

Fibrinogen-binding Inhibitor Peptide

≥97% (HPLC)

Synonym: Fibrinogen-γ Fragment 400-411

  • CAS Number 89105-94-2

  • Empirical Formula (Hill Notation) C50H80N18O16

  • Molecular Weight 1189.28

  •  MDL number MFCD00167528

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Properties

assay   ≥97% (HPLC)
composition   Peptide content, ~70%
storage temp.   −20°C
Gene Information   human ... FGG(2266)

Description

Amino Acid Sequence

His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val

Biochem/physiol Actions

Fibrinogen γ 400-411, a non-RGD containing sequence, is derived from plasmin digestion. If platelet activation is blocked with prostaglandin E1 blockade, it is required for the establishment of initial contact and support spreading but not firm adhesion on immobilized substrate. However, in activated platelets, single γ 400-411 sequence is no longer required for initiation of adhesion but becomes sufficient for firm adhesion. In contrast to the binding of whole fibrinogen, binding of fragment 400-411 does not lead to tyrosine phosphorylation for platelet proteins.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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