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G0923 Sigma-Aldrich

Golgicide A

≥98% (HPLC)

Synonym: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, CID 25113626, GCA

  • CAS Number 1005036-73-6

  • Empirical Formula (Hill Notation) C17H14F2N2

  • Molecular Weight 284.30

  •  PubChem Substance ID 329799717

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,
InChI Key   NJZHEQOUHLZCOX-FTLRAWMYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
storage temp.   room temp

Description

Application

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

GTP Binding Proteins (Low Molecular Weight)

The approximately 150 members of the human Ras superfamily of low molecular weight GTP binding proteins function as regulators of diverse cellular processes. Most Ras superfamily members have intrins...
Keywords: Absorption, Acetylations, Atomic absorption spectroscopy, Cancer, Cellular processes, Diseases, Enzyme activity, Farnesylations, Geranylgeranylations, Myristoylations, Palmitoylations, Post translational modifications, Rearrangements, Transduction

Peer-Reviewed Papers
15

References

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