G1251 Sigma-Aldrich

L-Glutamic acid

ReagentPlus®, ≥99% (HPLC)

Synonym: (S)-2-Aminopentanedioic acid, Glu

  • CAS Number 56-86-0

  • Linear Formula HO2CCH2CH2CH(NH2)CO2H

  • Molecular Weight 147.13

  •  Beilstein Registry Number 1723801

  •  EC Number 200-293-7

  •  MDL number MFCD00002634

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895052



Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.


1 kg in poly bottle

100, 500 g in poly bottle

5 kg in poly drum


L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.

Legal Information

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 

Milli-Q® Water Purification Solutions
Protocols & Articles


HPLC Analysis of Cysteine Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cysteine Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, High performance liquid chromatography

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites


Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Mitochondria participate in key metabolic reactions of the cell and regulate crucial signaling pathways including apoptosis. Although several approaches are available to study mitochondrial function ...
Keywords: Apoptosis, Buffers, Cell culture, Cell disruption, Centrifugation, Diffusion, Genetic, Genetics, Homogenization, Morphogenesis, Oxidations, Phase transitions, Phosphorylations, Respiration, Respiratory, Solvents

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Amino Acids Reference Chart

Amino acids are the 21 standard compounds or building blocks that make up peptides and proteins, including DNA. Each amino acid is structured from an amino group and a carboxyl group bound to a tetra...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers


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