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G1501 Sigma-Aldrich

L-Glutamic acid potassium salt monohydrate

≥99% (HPLC), powder

Synonym: (S)-2-Aminopentanedioic acid, L-α-Aminoglutaric acid potassium salt, L-2-Aminopentanedioic acid potassium salt, Glu, Potassium L-glutamate

  • CAS Number 6382-01-0

  • Empirical Formula (Hill Notation) C5H8KNO4 · H2O

  • Molecular Weight 203.23

  •  Beilstein/REAXYS Number 3637377

  •  MDL number MFCD00150343

  •  PubChem Substance ID 24895063

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, Neuroscience, Neurotransmission,
InChI Key   XIBUKSQTWSKJMQ-QTNFYWBSSA-M
assay   ≥99% (HPLC)
form   powder
color   white
Gene Information   human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Description

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Application

L-Glutamic acid potassium salt monohydrate has been used-
• for the purification of tubulins from bovine brain
• in stock solution for the preparation of quenching buffer during the formationof dual-color polarity-marked fluorescent microtubule seeds
• the preparation of cell free extracts devoid of RF2 (release factor 2) from Escherichia coli strains
• preparation of stock solutions during culture of Arabidopsis plants

Packaging

1 kg in poly bottle

100, 500 g in poly bottle

Biochem/physiol Actions

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington’s disease and Parkinson’s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MA1450000

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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