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G154 Sigma-Aldrich

Gabapentin

solid

Synonym: 1-(Aminomethyl)-cyclohexaneacetic acid, Neurontin

  • CAS Number 60142-96-3

  • Empirical Formula (Hill Notation) C9H17NO2

  • Molecular Weight 171.24

  •  Beilstein/REAXYS Number 2359739

  •  EC Number 262-076-3

  •  MDL number MFCD00865286

  •  PubChem Substance ID 24278159

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Description

Application

Gabapentin has been used:
• as the α2δ-ligand to examine whether the allyl isothiocyanate (AITC) sensitized thermal aversion assay might be useful as a screening method for the identification of presumptive analgesics
• dissolved in uptake buffer which is used to measure the to measure ASP (trans-4-[4-(Dimethylamino)styryl]-1-methylpyridinium iodide) substrate by organic cation transporter type 2 (OCTN2) using liquid chromatography - mass spectrometry
• used as an analgesic adjuvant for intraperitoneal injections

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Anticonvulsant with unknown mechanism of action; crosses the blood brain barrier; increases GABA concentrations in the brain and reduces excitatory amino acid neurotransmission, perhaps through its effects on voltage-gated calcium channels; exhibits antinociceptive, anxiolytic, neuroprotective and anti-epileptic effects.

Gabapentin serves as a ligand for the α2δ subunit of L-type calcium channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GU6496000

Documents

Certificate of Analysis

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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