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G2879 Sigma-Aldrich

Glycine hydrochloride

≥99% (HPLC)

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

  • CAS Number 6000-43-7

  • Linear Formula H2NCH2CO2H · HCl

  • Molecular Weight 111.53

  •  EC Number 227-841-8

  •  MDL number MFCD00012872

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895108

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, GABA and Glycine Receptor Modulators, Glycinergics, Ion Channels,
Quality Level   200
assay   ≥99% (HPLC)
mp   176-180 °C (lit.)
SMILES string   Cl.NCC(O)=O
InChI   1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
InChI key   IVLXQGJVBGMLRR-UHFFFAOYSA-N

Description

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Glycine hydrochloride has been used:
• in the preparation of glycine-HCl buffer
• to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
• to regenerate the sensor to elute the bound C-reactive protein (CRP)

Packaging

1 kg in poly bottle

100, 500 g in poly bottle

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia and reperfusion.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
WGK 1
RTECS 
MC0560000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Protocols

Stripping and Reprobing Western Blotting Membranes

Western blotting is a commonly used technique for studying protein function and localization. Typically, protein samples are separated by SDS-PAGE and transferred to a nitrocellulose or PVDF membrane...
Keywords: Buffers, Detergents, Immobilization, PAGE, Western blot

Peer-Reviewed Papers
15

References

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