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G2911 Sigma-Aldrich

GF 109203X

synthetic, ≥90% (HPLC)

Synonym: 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I

  • CAS Number 133052-90-1

  • Empirical Formula (Hill Notation) C25H24N4O2

  • Molecular Weight 412.48

  •  MDL number MFCD00236428

  •  PubChem Substance ID 329799908

  •  NACRES NA.77

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Properties

Related Categories Autophagy, Autophagy Activators, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
Quality Level   100
biological source   synthetic
InChI Key   QMGUOJYZJKLOLH-UHFFFAOYSA-N
assay   ≥90% (HPLC)
solubility   DMSO: soluble (~1 mg/ml)
storage temp.   2-8°C

Description

Application

GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Quantity

For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UX9590000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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