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G5417 SAFC

Glycine

PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

  • CAS Number 56-40-6

  • Linear Formula NH2CH2COOH

  • Molecular Weight 75.07

  •  Beilstein/REAXYS Number 635782

  •  EC Number 200-272-2

  •  MDL number MFCD00008131

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895210

  •  NACRES NA.25

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Properties

Related Categories Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z,
biological source   non-animal source
grade   EP
  JP
  USP
product line   PharmaGrade
assay   ≥98.5%
form   crystalline powder
mfr. no.   Ajinomoto
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, heavy metals, trace metals, residual solvents, tested
pH   5.9-6.4
pKa (25 °C)   2.35
mp   240 °C (dec.) (lit.)
solubility   H2O: 100 mg/mL
UV absorption   λ: 260 nm Amax: ≤0.04
  λ: 260 nm Amax: -0.006
  λ: 280 nm Amax: ≤0.04
  λ: 280 nm Amax: -0.003
suitability   suitable for manufacturing use
Featured Industry   Pharmaceutical (small molecule)
foreign activity   cytotoxicity, tested
SMILES string   NCC(O)=O
InChI   1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI key   DHMQDGOQFOQNFH-UHFFFAOYSA-N
Gene Information   rat ... Grin2a(24409)

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.
To request the Enhanced Quality Product Documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement.

Application

Glycine is a non-essential amino acid. It is the simplest of the amino acids and plays various roles in biology. It is structurally unique among the biological amino acids in that it does not have an asymmetric center, and thus is not chiral. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles

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Peer-Reviewed Papers
15

References

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