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G7403 Sigma-Aldrich

Glycine

BioXtra, ≥99% (titration)

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

  • CAS Number 56-40-6

  • Linear Formula NH2CH2COOH

  • Molecular Weight 75.07

  •  Beilstein Registry Number 635782

  •  EC Number 200-272-2

  •  MDL number MFCD00008131

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895306

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Properties

Related Categories Amino Acids, Biochemicals and Reagents, Core Bioreagents, General Reagents, Life Science Reagents for Protein Expression and Purification,
InChI Key   DHMQDGOQFOQNFH-UHFFFAOYSA-N
product line   BioXtra
assay   ≥99% (titration)
form   powder
impurities   Insoluble matter, passes filter test
ign. residue   ≤0.05%
loss   ≤0.05% loss on drying, HV, 20-26 °C
pKa (25 °C)   2.35
mp   240 °C (dec.) (lit.)
solubility   1 M HCl: 1 M, clear, colorless
anion traces   chloride (Cl-): ≤0.005%
  sulfate (SO42-): ≤0.005%
cation traces   Al: ≤0.0005%
  As: ≤0.00001%
  Ba: ≤0.0005%
  Bi: ≤0.0005%
  Ca: ≤0.001%
  Cd: ≤0.0005%
  Co: ≤0.0005%
  Cr: ≤0.0005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Li: ≤0.0005%
  Mg: ≤0.0005%
  Mn: ≤0.0005%
  Mo: ≤0.0005%
  NH4+: ≤0.02%
  Na: ≤0.005%
  Ni: ≤0.0005%
  Pb: ≤0.0005%
  Sr: ≤0.0005%
  Zn: ≤0.0005%
absorption   A1M/260, 1 M HCl ≤0.04
  A1M/280, 1 M HCl ≤0.04
UV absorption   λ: 260 nm Amax: ≤0.04
  λ: 260 nm Amax: ≤0.04
  λ: 260 nm Amax: 0.003
  λ: 260 nm Amax: 0.006
Gene Information   rat ... Grin2a(24409)

Description

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Packaging

1 kg in poly bottle

100, 250 g in poly bottle

Application

Glycine has been used to quench unreacted aldehyde during sample (nuclei) preparation for scanning electron microscope. It has also been used for sample fixation in the process of immunolabeling.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
MB7600000
Protocols & Articles

Protocols

Chromatin Immunoprecipitation Kit CHP1 Protocol

Product Description Storage/Stability Workflow Preparation Instructions Procedure Analysis Troubleshooting Guide Frequently Asked Questions Materials References Poster & Application Note
Keywords: AGE, Amplification, Cell culture, Cell disruption, Centrifugation, Chromatin immunoprecipitation, DNA purification, DNA replication, Digestions, Electrophoresis, Evaporation, Gel electrophoresis, Genomics, Homogenization, Immunoprecipitation, Individual protein Immunoprecipitation, Molecular biology, Molecular probes, Nucleic acid annealing, Nucleic acid hybridization, Polymerase chain reaction, Polymerase chain reaction - quantitative, Precipitation, Purification, Recombination, Sample preparations, Size-exclusion chromatography, Sonication, Transcription, Transduction, Whole genome amplification

Related Content

Amino Acids Reference Chart

Amino acids are the 21 standard compounds or building blocks that make up peptides and proteins, including DNA. Each amino acid is structured from an amino group and a carboxyl group bound to a tetra...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

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