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G8634 Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), powder

Synonym: GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

  • CAS Number 94825-44-2

  • Empirical Formula (Hill Notation) C10H12Li4N5O13P3S

  • Molecular Weight 562.98

  •  Beilstein/REAXYS Number 8182249

  •  EC Number 305-606-1

  •  MDL number MFCD00135151

  •  PubChem Substance ID 24895344

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,
InChI Key   AMQXJFWJOAWCPV-ZVQJTLEUSA-J
assay   ≥75% (HPLC)
form   powder
color   white to off-white
solubility   H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
shipped in   dry ice
storage temp.   −20°C

Description

Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
• as a component of lysis buffer
• in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
• to couple with G- protein α, to study its effect on kinase activity

Packaging

1, 5, 10, 25 mg in glass bottle

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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