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G8923 Sigma-Aldrich

GANT58

≥98% (HPLC)

Synonym: 2,3,4,5-Tetra(4-pyridyl)thiophene, 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine

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Properties

Related Categories Angiogenic Factors, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   USWLOKMMUTWFMD-UHFFFAOYSA-N
assay   ≥98% (HPLC)
color   white to pale yellow
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

GANT58 is a Hedgehog signaling pathway inhibitor. GANT58 inhibits the hedgehog signaling pathway downstream of Smo. GANT58 inhibits Gli transcriptional activity, and reduces cellular levels of the Hh pathway components Gli1, Shh, and patched.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Peer-Reviewed Papers
15

References

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