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H3656 Sigma-Aldrich

trans-4-Hydroxy-L-proline

microbial, suitable for cell culture

Synonym: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp

  • CAS Number 51-35-4

  • Empirical Formula (Hill Notation) C5H9NO3

  • Molecular Weight 131.13

  •  Beilstein/REAXYS Number 81441

  •  EC Number 200-091-9

  •  MDL number MFCD00064320

  •  PubChem Substance ID 329815200

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Properties

Related Categories A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids
biological source   microbial
assay   ≥98% (TLC)
application(s)   cell culture | mammalian: suitable
mp   273 °C (dec.) (lit.)
SMILES string   O[C@H]1CN[C@@H](C1)C(O)=O
InChI   1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key   PMMYEEVYMWASQN-DMTCNVIQSA-N

Description

Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is a chiral compound used in the synthesis of depsilairdin analogues; hydroxymethyl-2-pyrrolidinone (5) nucleoside analogs; enantiomerically pure polyheterocyclic spiro-β-lactams and the ABC-ring system of the antitumor antibiotic MPC1001.

Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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H5534 trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, ≥98.5%

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