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H3661 Sigma-Aldrich

4′-Hydroxydiclofenac

≥98% (HPLC)

Synonym: 4′-Hydroxy Diclofenac, [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid

  • CAS Number 64118-84-9

  • Empirical Formula (Hill Notation) C14H11Cl2NO3

  • Molecular Weight 312.15

  •  Beilstein/REAXYS Number 4198042

  •  MDL number MFCD01671980

  •  PubChem Substance ID 24895589

  •  NACRES NA.47

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors More...
InChI Key   KGVXVPRLBMWZLG-UHFFFAOYSA-N
Quality Level   200
assay   ≥98% (HPLC)
packaging   vial of 5 mg
storage temp.   −20°C

Description

General description

4′-Hydroxydiclofenac is an important metabolite of aceclofenac, seen mainly in rats. It is the important oxidative metabolite found in urine.

CYP2C9 metabolite of diclofenac.

Application

4′-Hydroxydiclofenac has been used to investigate the effect of gentiopicroside (GE) on human cytochrome P450 enzymes in vitro. It has also been used as an enzyme marker to study its metabolic activities in different in vitro liver models.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
AG6542800

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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