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H6012 Sigma-Aldrich

4-Hydroxyestrone

≥90% (HPLC)

Synonym: 1,3,5(10)-Estratriene-3,4-diol-17-one

  • CAS Number 3131-23-5

  • Empirical Formula (Hill Notation) C18H22O3

  • Molecular Weight 286.37

  •  MDL number MFCD00079358

  •  PubChem Substance ID 24895725

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   100
assay   ≥90% (HPLC)
form   powder
solubility   methanol: 10 mg/mL, clear, colorless to faintly brownish-yellow
shipped in   ambient
storage temp.   −20°C
SMILES string   [H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4c(O)c(O)ccc24
InChI   1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1
InChI key   XQZVQQZZOVBNLU-QDTBLXIISA-N

Description

Packaging

5, 25 mg in glass insert

Biochem/physiol Actions

4-Hydroxyestrone is an endogenous estrogen metabolite, which exhibits a strong neuroprotective effect against oxidative damage. It also provides effective protection against kanic acid-induced hippocampal oxidative damage in rats when compared to 17β-estradiol. 4-Hydroxyestrone regulates the angiogenic process during corpus luteum formation. It might be involved in an increased risk of cancer. 4-Hydroxyestrone is found in the early and mid-luteal phases.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
KG7749500
Flash Point(F) 
199.9 °F - closed cup
Flash Point(C) 
93.3 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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