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H6501 Sigma-Aldrich

DL-β-Hydroxybutyric acid sodium salt

~98%

Synonym: (±)-3-Hydroxybutanoic acid sodium salt

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Properties

Related Categories Activity, Activity Other, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates More...
assay   ~98%
storage temp.   2-8°C
SMILES string   [Na].CC(O)CC(O)=O
InChI   1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1
InChI key   NBPUSGBJDWCHKC-UHFFFAOYSA-M

Description

Application

DL-β-Hydroxybutyric acid sodium salt has been used:
• as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows
• to investigate its anticonvulsant effects in epilepsy induced rats
• to induce hyperketonemia in Holstein dairy cows

Packaging

5, 25, 100 g in poly bottle

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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