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H7125 Sigma-Aldrich

Histamine

≥97.0%

Synonym: 2-(4-Imidazolyl)ethylamine

  • CAS Number 51-45-6

  • Empirical Formula (Hill Notation) C5H9N3

  • Molecular Weight 111.15

  •  Beilstein Registry Number 2012

  •  EC Number 200-100-6

  •  MDL number MFCD00005210

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895783

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   NTYJJOPFIAHURM-UHFFFAOYSA-N
assay   ≥97.0%
bp   167 °C/0.8 mmHg(lit.)
mp   83-84 °C (lit.)
storage temp.   −20°C
Gene Information   human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
rat ... Hrh1(24448), Hrh3(85268)

Description

Packaging

1, 5, 25 g in glass bottle

Application

Histamine has been used:
• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Biochem/physiol Actions

Endogenous H1 and H2 histamine receptor agonist; H1 activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

General description

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
MS1050000

Making Headway
Protocols & Articles

Articles

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, Derivatizations, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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