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  • H7779 - Retinoic acid p-hydroxyanilide

H7779 Sigma-Aldrich

Retinoic acid p-hydroxyanilide


Synonym: 4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide

  • CAS Number 65646-68-6

  • Empirical Formula (Hill Notation) C26H33NO2

  • Molecular Weight 391.55

  •  MDL number MFCD00792674

  •  PubChem Substance ID 24278472

  •  NACRES NA.77



Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research,
biological source   synthetic (organic)
assay   ≥95%
form   powder
color   yellow to yellow-orange
storage temp.   −20°C



5 mg in glass bottle

Biochem/physiol Actions

Vitamin A acid analogue with antiproliferative activity in cultured human breast cancer cells; induces apoptosis in malignant hemopoietic cell lines.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H7779.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
In what solvents can productH7779, Retinoic acid p-hydroxyanilide, be dissolved?
Product H7779, Retinoic acid p-hydroxyanilide, can be dissolved in DMSO (25 mg/ml) and ethanol (25 mg/ml).
How can one store a solution of product H7779, Retinoic acid p-hydroxyanilide?
A solution of product H7779, Retinoic acid p-hydroxyanilide, can be aliquoted and stored at -20 degrees C for up to 3 months. Solutions should be protect from light.
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Protocols & Articles


Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers


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