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H8787 Sigma-Aldrich

HA 14-1

≥95% (CHN/NMR), powder

Synonym: 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate

  • CAS Number 65673-63-4

  • Empirical Formula (Hill Notation) C17H17BrN2O5

  • Molecular Weight 409.23

  •  MDL number MFCD00218213

  •  PubChem Substance ID 24724505

  •  NACRES NA.77

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Properties

Related Categories Anti-Proliferative Agents, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index,
InChI Key   SXJDCULZDFWMJC-UHFFFAOYSA-N
assay   ≥95% (CHN/NMR)
form   powder
solubility   DMSO: 26 mg/mL
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... BCL2(596)
mouse ... BCL2(12043)
rat ... BCL2(24224)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers
15

References

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