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I0634 Sigma-Aldrich

Ionomycin calcium salt from Streptomyces conglobatus

powder, ≥98% (HPLC)

  • CAS Number 56092-82-1

  • Empirical Formula (Hill Notation) C41H70CaO9

  • Molecular Weight 747.07

  •  Beilstein/REAXYS Number 1416163

  •  MDL number MFCD00083634

  •  PubChem Substance ID 329815321

  •  NACRES NA.77

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
Quality Level   300
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
  protect from light
color   white to off-white
solubility   DMSO: 10 mg/mL
  ethanol: soluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C
SMILES string   C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI   1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key   WKRWUYKLUMMAKG-WYGBAUISSA-L

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.

Preparation Note

Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
NO0650000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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