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I0659 Sigma-Aldrich

Ingenol-3-angelate

≥98% (HPLC), amorphous

Synonym: (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclpropa[e][10]annulen-6-yl (2Z)-2-methylbut-2-enoate, 3-Angeloylingenol, 3-Ingenyl angelate, I3A, Ingenol mebutate, PEP005

  • CAS Number 75567-37-2

  • Empirical Formula (Hill Notation) C25H34O6

  • Molecular Weight 430.53

  •  PubChem Substance ID 24724507

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Properties

InChI Key   VDJHFHXMUKFKET-WDUFCVPESA-N
assay   ≥98% (HPLC)
form   amorphous
color   clear
solubility   DMSO: >1 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cell lines. Ingenol 3-Angelate is a protein kinase C activator that displays potent antileukemic activity. Ingenol 3-Angelate (ingenol mebutate) is used for treatment of actinic keratosis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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