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I0661 Sigma-Aldrich

(−)-Indolactam V

≥96% (HPLC)

Synonym: (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one

  • CAS Number 90365-57-4

  • Empirical Formula (Hill Notation) C17H23N3O2

  • Molecular Weight 301.38

  •  MDL number MFCD00151197

  •  PubChem Substance ID 329815323

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I,
Quality Level   100
assay   ≥96% (HPLC)
form   white powder
solubility   DMSO: >10 mg/mL, clear
storage temp.   −20°C
SMILES string   CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
InChI   1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
InChI key   LUZOFMGZMUZSSK-LRDDRELGSA-N

Description

Packaging

1 mg in glass bottle

Biochem/physiol Actions

(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.

(−)-Indolactam V is naturally present in Streptoverticillium blastmyceticum. It serves as a precursor to the teleocidin class which are alkaloids. It is a the pharmacophore of lyngbyatoxin and teleocidins.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Biological processes, Cancer, Catalysis, Cell signaling, Degradations, Diabetes, Gastrointestinal, Gene expression, Immobilization, Phosphorylations, Pulsed discharge ionization detector, Transcription, Ubiquitinations

Peer-Reviewed Papers
15

References

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