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I134 Sigma-Aldrich

L-N5-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

Synonym: L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride

  • CAS Number 150403-88-6

  • Empirical Formula (Hill Notation) C7H15N3O2 · HCl

  • Molecular Weight 209.67

  •  MDL number MFCD00153817

  •  PubChem Substance ID 329815348

  •  NACRES NA.26

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
  under inert gas
color   white to beige
solubility   H2O: 2 mg/mL, clear (warmed)
storage temp.   −20°C
SMILES string   CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl
InChI   1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1
InChI key   JIBZSGQTCBWUKL-RGMNGODLSA-N

Description

Application

L-N5-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.

Packaging

1, 5, 25 mg in glass bottle

Biochem/physiol Actions

A potent irreversible inhibitor of nitric oxide synthase.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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