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I2142 Sigma-Aldrich

KN-62

≥95%, powder

Synonym: (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

  • CAS Number 127191-97-3

  • Empirical Formula (Hill Notation) C38H35N5O6S2

  • Molecular Weight 721.84

  •  MDL number MFCD00083180

  •  PubChem Substance ID 24895961

  •  NACRES NA.77

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Properties

Related Categories A to C, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Calcium/Calmodulin-Dependent Protein Kinase (CaMK),
assay   ≥95%
form   powder
color   yellow
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
  methanol: 10 mg/mL
  DMSO: 12 mg/mL
  chloroform: 20 mg/mL
storage temp.   −20°C
SMILES string   O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
InChI   1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
InChI key   RJVLFQBBRSMWHX-DHUJRADRSA-N
Gene Information   human ... P2RX7(5027)

Description

Packaging

.5, 1 mg in glass bottle

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

Features and Benefits

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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