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I2285 Sigma-Aldrich

IPA-3

≥95% (HPLC), powder

Synonym: 1,1′-Disulfanediyldinaphthalen-2-ol

  • CAS Number 42521-82-4

  • Empirical Formula (Hill Notation) C20H14O2S2

  • Molecular Weight 350.45

  •  MDL number MFCD00388917

  •  PubChem Substance ID 329815364

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, I
InChI Key   RFAXLXKIAKIUDT-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
color   off-white to yellow
solubility   DMSO: >20 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

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Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

STE20

The Ste20 (Sterile 20) protein kinase family consists of enzymes with sequence homology to the yeast MAP4K Ste20p in the pheromone response pathway. Based on phylogenetic relationships, they can be d...
Keywords: Adhesion, Angiogenesis, Apoptosis, Atomic absorption spectroscopy, Cancer, Catalysis, Ion-exchange chromatography, Morphogenesis, Phosphorylations, Rearrangements, Transcription, Transduction, transformation

Peer-Reviewed Papers
15

References

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