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I2409 Sigma-Aldrich

Ilmofosine

≥97% (NMR), semisolid (waxy)

Synonym: 1-Hexadecylmercapto-2-methoxymethyl-3-propyl phosphoric acid monocholine ester, BM 41.440

  • CAS Number 83519-04-4

  • Empirical Formula (Hill Notation) C26H56NO5PS

  • Molecular Weight 525.77

  •  MDL number MFCD00869023

  •  PubChem Substance ID 24724510

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   ODEDPKNSRBCSDO-UHFFFAOYSA-N
assay   ≥97% (NMR)
form   semisolid (waxy)
solubility   H2O: 10 mg/mL
originator   Roche
storage temp.   −20°C

Description

Packaging

1 mg in glass bottle

Air-sensitive, sealed under nitrogen

Biochem/physiol Actions

Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560 nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30 μg/mL.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
JH4758000

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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