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I4159 Sigma-Aldrich

ITSA-1

≥98% (HPLC), solid

Synonym: 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole, Inhibitor-1 of Trichostatin A, N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
InChI Key   UVNLAUGZMOPBPR-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: ~28 mg/mL
storage temp.   2-8°C

Description

Packaging

25 mg in glass bottle

Biochem/physiol Actions

ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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