I7378 Sigma-Aldrich


98.5-100.5% (in accordance with BP)

Synonym: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

  • CAS Number 53-86-1

  • Empirical Formula (Hill Notation) C19H16ClNO4

  • Molecular Weight 357.79

  •  Beilstein/REAXYS Number 497341

  •  EC Number 200-186-5

  •  MDL number MFCD00057095

  •  PubChem Substance ID 24278173

  •  NACRES NA.77



Related Categories A to C, Antitumor Agents, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   200
assay   98.5-100.5% (in accordance with BP)
form   powder or crystals
impurities   ≤0.1% sulphated ash
  ≤0.5% related substance (TLC)
  ≤20 ppm heavy metals
loss   ≤0.5% loss on drying
mp   158-162 °C
Mode of action   enzyme | inhibits
originator   Pfizer
Gene Information   human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)


General description

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.


Indomethacin has been used:
• as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
• as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
• in the inhibition of prostaglandin E2 (PGE2) in T cells


10, 25, 100 g in glass bottle

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

GHS06  GHS06
Signal word 
Hazard statements 
Precautionary statements 
UN 2811 6.1 / PGI
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


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