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I8021 Sigma-Aldrich

L-N6-(1-Iminoethyl)lysine dihydrochloride

Synonym: L-Lysine ω-acetamidine dihydrochloride, L-NIL dihydrochloride

  • CAS Number 159190-45-1

  • Empirical Formula (Hill Notation) C8H17N3O2 · 2 HCl

  • Molecular Weight 260.16

  •  MDL number MFCD00270890

  •  PubChem Substance ID 24278827

  •  NACRES NA.77

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Properties

Related Categories Application Index, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
biological source   synthetic (organic)
assay   ≥97% (HPLC)
form   powder
solubility   water: 50 mg/mL, clear, colorless
storage temp.   −20°C
SMILES string   Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
InChI   1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
InChI key   OQIBCXRAFAHXMM-KLXURFKVSA-N
Gene Information   human ... NOS2(4843)

Description

Application

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
• to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
• to study its effects on leptin-induced inflammation in hepatocytes
• to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Packaging

10 mg in glass insert

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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