EMAIL THIS PAGE TO A FRIEND
J4774 Sigma-Aldrich

JX401

>98% (HPLC), solid

Synonym: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine

  • CAS Number 349087-34-9

  • Empirical Formula (Hill Notation) C21H25NO2S

  • Molecular Weight 355.49

  •  MDL number MFCD02038777

Purchase

Properties

assay   >98% (HPLC)
form   solid
color   off-white
solubility   DMSO: >5 mg/mL

Description

Biochem/physiol Actions

JX401 is a potent non-cytotoxic, membrane permeable p38α inhibitor. It is highly specific for p38α with an IC50 value of 32 nM while showing no inhibition for p38γ even at 10 μM. JX401 rescued yeast growth in a dose-dependent manner in p38-expressing cultures and reversibly inhibited myoblast differentiation in mammalian cells in culture.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???
Protocols & Articles

Articles

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?