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K0254 Sigma-Aldrich

Kanamycin solution from Streptomyces kanamyceticus

50 mg/mL in 0.9% NaCl, BioReagent, liquid, sterile-filtered, suitable for cell culture

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Properties

Related Categories A - K, Aminoglycosides, Antibacterial, Antibiotic Solutions, Antibiotics,
biological source   Streptomyces kanamyceticus
InChI Key   SBUJHOSQTJFQJX-NOAMYHISSA-N
sterility   sterile-filtered
product line   BioReagent
form   liquid
potency   50-60 mg per mL
concentration   50 mg/mL in 0.9% NaCl
application(s)   cell culture | plant: suitable
impurities   endotoxin, tested
suitability   suitable for cell culture
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
  mycoplasma
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Caution

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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