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K1388 Sigma-Aldrich

KT 5823

≥85% (HPLC), lyophilized powder

  • CAS Number 126643-37-6

  • Empirical Formula (Hill Notation) C29H25N3O5

  • Molecular Weight 495.53

  •  MDL number MFCD09878278

  •  PubChem Substance ID 24896206

  •  NACRES NA.77

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Description

General description

KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na+/I symporter (NIS) expression.

Application

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.

Biochem/physiol Actions

Selective inhibitor of PKG.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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