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K1519 Sigma-Aldrich

KM11060

≥98% (HPLC)

Synonym: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chloride Channel Modulators, Ion Channels, Monovalent Ion Channels,
InChI Key   GIEHIZKCIZLXLF-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
solubility   DMSO: >10 mg/mL
storage temp.   room temp

Description

Biochem/physiol Actions

KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Chloride Channels

From a functional viewpoint, several different types of chloride channels showing different electrophysiological and regulatory characteristics have been described. These can be loosely grouped into ...
Keywords: Anti-depressants, Cancer, Gene expression, Hormones, Ligands, Neurotransmitters, Phosphorylations

Peer-Reviewed Papers
15

References

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