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K2389 Sigma-Aldrich

Kainic acid monohydrate

≥98% (HPLC), from Digenea simplex

Synonym: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

  • CAS Number 58002-62-3

  • Empirical Formula (Hill Notation) C10H15NO4 · H2O

  • Molecular Weight 231.25

  •  MDL number MFCD00150833

  •  PubChem Substance ID 24724520

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
biological source   Digenea simplex
InChI Key   FZNZRJRSYLQHLT-SLGZUKMRSA-N
assay   ≥98% (HPLC)
color   white
solubility   H2O: >10 mg/mL
storage temp.   2-8°C

Description

Application

Kainic acid monohydrate has been used:
• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Ionotropic glutamate receptors form ion channels, and conduct Na+ and K+ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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K0250 Kainic acid monohydrate, ≥99% (TLC)

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