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K4264 Sigma-Aldrich

KR-62436 hydrate

≥95%, powder

Synonym: 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   100
assay   ≥95%
form   powder
color   white to beige
solubility   H2O: 5 mg/mL, clear
storage temp.   2-8°C
SMILES string   O.Cl.Cl.O=C(CNCCNc1ccc(cn1)C#N)N2N=CCC2C#N
InChI   1S/C14H15N7O.2ClH.H2O/c15-7-11-1-2-13(19-9-11)18-6-5-17-10-14(22)21-12(8-16)3-4-20-21;;;/h1-2,4,9,12,17H,3,5-6,10H2,(H,18,19);2*1H;1H2
InChI key   FQZOFSJMRKZMSV-UHFFFAOYSA-N

Description

Packaging

5, 20 mg in glass bottle

Biochem/physiol Actions

KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC50 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Neuropeptidases

The term "neuropeptidases" refers to those enzymes that participate in the inactivation of synaptically released neuropeptides and therefore serve to turn off the generated peptide signal. In general...
Keywords: AGE, Alzheimer Disease, Angiogenesis, Anti-inflammatory agents, Cancer, Cardiovascular, Cell proliferation, Degradations, Diabetes, Digestions, Gene expression, Hormones, Inflammation, Metabolism, Neurotransmitters, Normal-phase chromatography, Obesity, Respiratory, Schizophrenia, Sequencing

Peer-Reviewed Papers
15

References

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