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K4389 Sigma-Aldrich

KR-32568

≥98% (HPLC), solid

Synonym: [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
InChI Key   DTLDHYBZLVASJQ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: ~10 mg/mL
storage temp.   2-8°C
Gene Information   human ... SLC9A1(6548)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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