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L135 Sigma-Aldrich

L-741,626

≥98% (HPLC)

Synonym: (±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

  • CAS Number 81226-60-0

  • Empirical Formula (Hill Notation) C20H21ClN2O

  • Molecular Weight 340.85

  •  MDL number MFCD00953632

  •  PubChem Substance ID 24278529

  •  NACRES NA.77

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Properties

Related Categories Antagonists - Dopaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: ≥20 mg/mL
  ethanol: 24 mg/mL
  H2O: insoluble
storage temp.   room temp
SMILES string   OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4
InChI   1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChI key   LLBLNMUONVVVPG-UHFFFAOYSA-N
Gene Information   human ... DRD2(1813), DRD3(1814), DRD4(1815)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Selective D2 dopamine receptor antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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