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L137 Sigma-Aldrich

L-733,060 hydrochloride

solid, ≥98% (HPLC)

Synonym: (2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

  • CAS Number 148687-76-7

  • Empirical Formula (Hill Notation) C20H19F6NO · HCl

  • Molecular Weight 439.82

  •  MDL number MFCD06798982

  •  PubChem Substance ID 24278530

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Properties

assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: >10 mg/mL
  H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... TACR1(6869)

Description

Biochem/physiol Actions

Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.

Legal Information

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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