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L2545 Sigma-Aldrich

LY225910

≥98% (HPLC)

Synonym: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone

  • CAS Number 133040-77-4

  • Empirical Formula (Hill Notation) C27H24BrN3O2

  • Molecular Weight 502.40

  •  MDL number MFCD00907856

  •  PubChem Substance ID 329817399

  •  NACRES NA.77

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.

LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.

Features and Benefits

This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Flash Point(F) 
638.6 - 761 °F
Flash Point(C) 
337 - 405 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Cholecystokinin and Gastrin Receptors

The naturally occurring peptides, cholecystokinin (CCK) and gastrin closely resemble each other at their carboxyl terminus, which is the biologically active portion of the molecules. Both peptides co...
Keywords: Adhesion, Atomic absorption spectroscopy, Cancer, Dopamine agents, Gene expression, Hormones, Neurotransmitters, Phosphorylations, Respiratory, Transduction

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