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L9167 Sigma-Aldrich

LWH-63 hydrochloride

≥98% (HPLC), solid

Synonym: 4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride, NIH-3

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CRF, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   DKVWSJKPRJIFPC-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   light brown
solubility   DMSO: ~10 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Non-peptide CRF1 corticotrophin-releasing factor antagonist. Ki = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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