EMAIL THIS PAGE TO A FRIEND
M3949 Sigma-Aldrich

MST-312

≥98% (HPLC)

Synonym: N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]

  • CAS Number 368449-04-1

  • Empirical Formula (Hill Notation) C20H16N2O6

  • Molecular Weight 380.35

  •  MDL number MFCD24368986

  •  PubChem Substance ID 329817985

  •  NACRES NA.77

Purchase

Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   off-white to light tan
solubility   DMSO: ≥20 mg/mL
storage temp.   2-8°C
SMILES string   Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
InChI   1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChI key   MIQUEZGHEJGPJB-UHFFFAOYSA-N

Description

Application

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?