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M5644 Sigma-Aldrich

(±)-Methoxyverapamil hydrochloride

≥98%

Synonym: (±)-α-[3-[(2-(3,4-Dimethoxyphenyl)ethyl)methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride, D 600, Gallopamil

  • CAS Number 16662-47-8

  • Empirical Formula (Hill Notation) C28H40N2O5 · HCl

  • Molecular Weight 521.09

  •  MDL number MFCD00058000

  •  PubChem Substance ID 24277852

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Description

General description

Methoxyverapamil is a calmodulin antagonist. It controls flagellar glycoprotein redistribution by modulating calcium signalling. Methoxyverapamil impacts the effect of intracellular calcium levels and affects the sperm capacitation function.

Application

(±)-Methoxyverapamil hydrochloride has been used:
• as calcium channel antagonist in Schistosoma mansoni parasite
• as calcium entry blocker in cultured macrophages
• in the inhibition of L-type voltage gated Ca2+-channels

Packaging

50, 250 mg in poly bottle

Biochem/physiol Actions

Blocks L-type Ca2+ channels

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

UHPLC Analysis of Verapamil and Metabolites on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Verapamil and Metabolites on Titan™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

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