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M6885 Sigma-Aldrich

1-Methyluric acid

Synonym: 1-Methyl-2,6,8-trihydroxypurine, 1-U, 1MUA

  • CAS Number 708-79-2

  • Empirical Formula (Hill Notation) C6H6N4O3

  • Molecular Weight 182.14

  •  Beilstein/REAXYS Number 195190

  •  EC Number 211-905-7

  •  MDL number MFCD00042987

  •  PubChem Substance ID 24897125

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Properties

Related Categories Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides More...
InChI Key   QFDRTQONISXGJA-UHFFFAOYSA-N

Description

Application

1-Methyluric acid has been used:
• for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
• in turbidimetric assay of synthetic urine samples
• as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay

Packaging

50, 100 mg in poly bottle

Biochem/physiol Actions

1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6885.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

HPLC Analysis of Caffeine Metabolites and Analogs on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine Metabolites and Analogs on Discovery® C18
Keywords: Chromatography, Clinical, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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