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M7320 Sigma-Aldrich

N-Methylhistaprodifen dioxalate salt

≥98% (HPLC), solid

Synonym: N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]-ethanamine dioxalate salt

  • CAS Number 270079-48-6

  • Empirical Formula (Hill Notation) C21H25N3 · 2 C2H2O4

  • Molecular Weight 499.51

  •  MDL number MFCD09752603

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Properties

assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble <2 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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