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M8131 Sigma-Aldrich

α-Methyl-L-tyrosine

≥98% (TLC)

Synonym: L-2-Methyl-3-(4-hydroxy­phenyl)alanine, L-AMPT

  • CAS Number 672-87-7

  • Empirical Formula (Hill Notation) C10H13NO3

  • Molecular Weight 195.22

  •  Beilstein/REAXYS Number 2368400

  •  EC Number 211-599-5

  •  MDL number MFCD00064201

  •  PubChem Substance ID 24278155

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Neuroscience, Neurotransmission,
InChI Key   NHTGHBARYWONDQ-JTQLQIEISA-N
assay   ≥98% (TLC)
storage temp.   −20°C
Gene Information   human ... TH(7054)

Description

Application

α-Methyl-L-tyrosine is used to determine whether Fe2/ methamphetamine (METH) -induced cell death is dependent on cytosolic dopamine and iron mediated oxidative stress.

Packaging

1, 5 g in poly bottle

100, 250 mg in poly bottle

Biochem/physiol Actions

α-Methyl-L-tyrosine (L-AMPT) acts as a competitive inhibitor of tyrosine hydroxylase and inhibits the conversion of tyrosine to L-DOPA and eventually lowers dopamine synthesis in cytosol. AMPT at low concentrations can be used as a potent therapeutic for refractory dystonia or dyskinesia. It also helps in decreasing catecholamine concentration in pheochromocytoma patients.

Tyrosine hydroxylase inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Active isomer

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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